1. Cytotoxic Components of the Stony Coral   Montipora   sp.

제주도에서 채집된 석산호   Montipora   sp.에서 유의성 있는 brine shrimp lethality가 관찰되어 이의 활성성분 연구를 통하여 새로운 acetylene 화합물을 분리 정제하였다. 이들 물질은 5종의 인체암세포에 대하여 유의성 있는 항암활성을 나타내었으며 cell cycle에 대한 선택적인 억제작용이 확인되었다. 이는 암세포의 apoptosis를 유도하여 사멸케 하는 것으로 나타났다.

 
Ten new (1, 4-6, 9-14) and four known (2, 3, 7, 8) diacetylenes have been isolated from a brine shrimp active fraction of the methanolic extract of the stony coral Montipora sp. The structures were determined by combined spectroscopic methods. The compounds exhibited significant cytotoxicity against a small panel of human solid tumor cell lines. Montiporyne A (15), a previously reported congener, was also found to induce apoptosis in human colon tumor cell.   A new pyridinium alkaloid, montipyridine (1), has been isolated from the stony coral Montipora sp. The structure was established from spectroscopic data .

배복희 ,   Naseer Alam

1 . Book Hee Bae, Kwang Sik Im, Won Chul Choi, Jongki Hong, Chong-O Lee, Jae Su Choi, Byeng Wha Son, Jun-Im Song, and Jee H. Jung, New acetylenic compouns from the stony coral   Montipora   sp.,   J. Nat. Prod . ,   2000,   63, 1511-1514
2 . Alam, N.; Hong, J.; Lee, C.O.; Im, K.S.; Son, B.W.; Choi, J.S.; Choi, W.C.; Jung, J.H. ( 2001 ) Montipyridine, a new  pyridinium alkaloid from the stony coral   Montipora species,   J. Nat. Prod ., 64, 956-957.
3 . Alam, N.; Bae, B.H.; Hong, J.; Lee, C.O.; Im, K.S.; Jung, J.H. ( 2001 ) Cytotoxic diacetylenes from the stony coral   Montipora   species,   J. Nat. Prod ., 64, 1059-1063. 
4. Alam, N.; Hong, J.; Lee, C.O.; Choi, J. S.; Im, K.S.; Jung, J.H. ( 2002 ) Additional Cytotoxic Diacetylenes from the stony coral   Montipora   sp,   Chem. Pharm. Bulll ., 50,