박 장 수 사진
박 장 수
영문이름
Park, Jang Su
직위(직급)
교수
전화번호
(82-51) 510-2294 (실험실: 3243)
이메일
jaspark@pusan.ac.kr
사이트
http://chemlab.pusan.ac.kr/jaspark
연구분야
생화학

■ 학 력

1979 - 1983 부산대 화학과 (화학 이학사)

1983 - 1985 부산대 화학과 (생화학 이학석사)

1987 - 1991 일본 요코하마국립대 (생화학 이학박사)


■ 경 력

2009. 3. - 2009.8. 부산대학교 자연과학대학 학장

2005. 2. - 2008.9. 부산대학교 산학협력단 부단장

2004. 3. - 2005. 2. 부산대학교 자연과학대학 부학장

2004. 4. - 현재 부산대학교 자연과학대학 교수

2003. 12. - 2004. 2. 일본 오사카대학 단백질연구소 방문교수

2003. 9. - 2004. 2. 부산대학교 의ㆍ치예과 학과장

2002. 6. - 2003. 8. 부산대학교 자연과학대학 화학과 학과장

1999. 4. - 2004. 3. 부산대학교 자연과학대학 부교수

1997. 2. - 1999. 2. 미국 Indiana 대학 방문교수

1994. 12. - 1995. 2. 일본 Yokohama 국립대학 방문교수

1994. 4. - 1999. 3. 부산대학교 자연과학대학 조교수

1992. 3. - 1994. 3. 부산대학교 자연과학대학 전임강사

1991. 7. - 1992. 2. 일본 Yokohama 국립대학 객원연구원

 


■ Selected Publications

 

38. Comparison of Thermal Stress Induced Heat Shock Factor 1 (HSF1) in Goldfish and Mouse Hepatocyte Cultures, So-Sun Kim; Jae-Hyeong So; Jang-Su Park, Journal of Life Science. 2016-12 26:1360-1366(2016)

 

37. Identification, tissue distribution and characterization of two heat shock factors(HSFs) in goldfish(Carassius auratus) , So-Sun Kim, Ziwei Chang, Jang-Su Park*, Fish and Shellfish Immunology VOL.43. pp 375-386(2015)

 

 

36. Protonation Behavior of Histidine during HSF1 Activation by Physiological Acidification , Ming Lu, Jang-Su Park*

Journal of Cellular Biochemistry DOI : 10.1002/jcb.25051(2015)

 

 

35. Production of disulfide bond-rich peptides by fusion expression using small transmembrane proteins of Escherichia coli, Ziwei Chang, Ming Lu, Yunqi Ma, Dong-Geon Kwag, Seo-Hyun Kim, Ji-Min Park, Bo-Hye Nam, Young-Ok Kim, Cheul-Min An, Huayue Li, Jee H. Jung, and Jang-Su Park*, Amino Acids Vol. 47, pp. 579-587(2015)

 

 

34. Functional expression of Carassius auratus cytochrome P4501A in a novel Shewanella oneidensis expression system and application for the degradation of benzo[a]pyrene, Ziwei Chang, Ming Lu, Kwang-Jae Shon, Jang-Su Park*, Journal of Biotechnology Vol. 179, pp. 1-7(2014)

 

 

33. Potential role of HSP90 in mediating the interactions between estrogen receptor (ER) and aryl hydrocarbon receptor (AhR) signaling pathways, Ziwei Chang, Ming Lu, So-Sun Kim, Jang-Su Park*, Toxicology Letters Vol. 226, No. 1, pp. 6-13(2014)

 

 

32. Histidine (His83) is Essential for Heat Shock Factor 1 (HSF1) Activation in Protecting against Acid pH Stress, Ming Lu, Ziwei Chang, and Jang-Su Park*, Bull. Korean Chem. Soc. Vol. 34, No. 11, pp. 3409-3409(2013)

 

 

31. Molecular characterization of the aryl hydrocarbon receptor (AhR) pathway in goldfish (Carassius auratus) exposure to TCDD: The mRNA and protein levels, Ming Lu, Ziwei Chang, Min-Ji Bae, Seung Min Oh, Kyu-Hyuck Chung, Jang-Su Park*, Fish and Shellfish Immunology Vol. 35, pp. 469-479(2013)

 

 

30. Roles of His101 in DNA-binding domain of human heat shock factor 1 under acid pH environment, Lu, Ming; Kwon, Bobae; Chang, Ziwei; Park, Hyeon-Gyeong; Park, Jang-Su *, Bulletin of the Korean Chemical Society Vol. 33, No. 12, pp. 4201-4203(2012)

 

 

29. Functional HSF1 requires aromatic-participant interactions in protecting mouse embryonic fibroblasts against apoptosis via G2 cell cycle arrest, Chang, Ziwei; Lu, Ming; Park, Sung-Min; Park, Hyun-Kyung; Kang, Ho Sung; Pak,Youngshang; Park, Jang-Su*, Molecules and Cells Vol. 33, No. 5, pp. 465-470(2012)

 

 

28. Influence of divalent metal ions on E2-induced ER pathway in goldfish (Carassius auratus) hepatocytes, Chang, Ziwei; Lu, Ming; Lee, Keun Woo; Oh, Beom-Seok,Bae, Min-Ji; Park, Jang-Su*, Ecotoxicology and Environmental Safety Vol. 74, No. 8, pp. 2233?2239(2011)

 

 

27. Estrogenic Response in Male Bullfrog (Rana catesbeiana) Hepatocytes After Single or Combined Exposure to Cadmium (Cd) and 17beta-Estradiol (E2). Lee, Keun Woo; Chang, Ziwei; Oh, Beom-Seok; Lu, Ming; Park, Jang-Su. Bulletin of Environmental Contamination and Toxicology (2010), 85(5), 452-456.


26. Apoptotic activity of a new jasmonate analogue is associated with its induction of DNA damage. Zhao, Jing; Kang, Saeromi; Zhang, Xin; You, Song; Park, Jang-Su; Jung, Jee H.; Kim, Dong-Kyoo. Oncology Reports (2010), 24(3), 771-777.


25. Functional and structural characterization of apidaecin. Bang, Jeong-Kyu; Ravichandran; Murugan, N.; Kwak, Ock Keum; Jeon, Young Ho; Chung, Joo Hee; Lee, Kwon Woo; Park, Jae Hun; Kim, Suhkmann; Park, Jang-Su; Kang, Shin Won. Bulletin of the Korean Chemical Society (2010), 31(1), 209-212.


24. Aromatic-Participant Interactions Are Essential for Disulfide-Bond-Based Trimerization in Human Heat Shock Transcription Factor 1. Lu, Ming; Lee, Yun-Ju; Park, Sung-Min; Kang, Ho Sung; Kang, Shin Won; Kim, Suhkmann; Park, Jang-Su. Biochemistry (2009), 48(18), 3795-3797.


23. Alpha-helix 1 in the DNA-binding domain of heat shock factor 1 regulates its heat-induced trimerization and DNA-binding. Lu, Ming; Sohn, Kwang-Jea; Kim, Si-Won; Li, Chun-Ri; Kim, Suhkmann; Kim, Dong-Kyoo; Park, Jang-Su. Biochemical and Biophysical Research Communications (2009), 385(4), 612-617.


22. Environmental estrogenic effects and gonadal development in wild goldfish (Carassius auratus). Li, Chun-Ri; Lee, Sang-Hoon; Kim, So-Sun; Kim, Andre; Lee, Keun Woo; Lu, Ming; Kim, Hee-Eun; Kwak, Im-Jung; Lee, Yun-Ju; Kim, Dong-Kyoo; Lee, Jung-Sick; Kang, Shin-Won; Huh, Min-Do; Chung, Kyu-Hyuck; Park, Jang-Su. Environmental Monitoring and Assessment (2009), 150(1-4), 397-404


21. Zn2+-dependent single-stranded DNA binding and DNA replication activities in replication protein A. Lu, Ming; Kwak, Im-Jung; Kim, Andre; Kim, Dong-Kyoo; Lee, Suk-Hee; Park, Jang-Su. Bulletin of the Korean Chemical Society (2009), 30(12), 2867-2868.


20. Identification of estrogen-like effects and biologically active compounds in river water using bioassays and chemical analysis. Oh, Seung Min; Kim, Ha Ryong; Park, Hye Kyung; Choi, Kyunghee; Ryu, Jisung; Shin, Ho Sang; Park, Jang-Su; Lee, Jung Sick; Chung, Kyu Hyuck. Science of the Total Environment (2009), 407(21), 5787-5794.


19. Two Distinct Disulfide Bonds Formed in Human Heat Shock Transcription Factor 1 Act in Opposition To Regulate Its DNA Binding Activity. Lu, Ming; Kim, Hee-Eun; Li, Chun-Ri; Kim, Sol; Kwak, Im-Jung; Lee, Yun-Ju; Kim, So-Sun; Moon, Ji-Young; Kim, Cho Hee; Kim, Dong-Kyoo; Kang, Ho Sung; Park, Jang-Su. Biochemistry (2008), 47(22), 6007-6015.


18. Apoptotic activity of fatty acid derivatives may correlate with their inhibition of DNA replication. Miao, Chunhui; Du, Juan; Dang, Hung The; Jeong, In-Hye; You, Song; Park, Jang-Su; Jung, Jee H.; Kim, Dong-Kyoo. International Journal of Oncology (2008), 33(6), 1291-1298.


17. Probing the structural requirement of 7-azabicyclo[2.2.1]hept-2-ene that functions as Wip1 inhibitor. Kim, Suhkmann; Pak, Eun Sik; Jin, Jong Sung; Won, Mi Sook; Park, Jang-Su; Kwang, Shin Won; Bang, Jeong-Kyu. Bulletin of the Korean Chemical Society (2008), 29(8), 1575-1578.


16. Cytotoxicity of p-tyrosol and its derivatives may correlate with the inhibition of DNA replication initiation. Ahn, Eun-Young; Jiang, Yahong; Zhang, Yanjun; Son, Eun Mi; You, Song; Kang, Shin-Won; Park, Jang-Su; Jung, Jee H.; Lee, Burm-Jong; Kim, Dong-Kyoo. Oncology Reports (2008), 19(2), 527-534.


15. A sensitive and reliable quantification method for Bisphenol A based on modified competitive ELISA method. Kim, Andre; Li, Chun-Ri; Jin, Chun-Feng; Lee, Keun Woo; Lee, Sang-Hoon; Shon, Kwang-Jae; Park, Nam Gyu; Kim, Dong-Kyoo; Kang, Shin-Won; Shim, Yoon-Bo; Park, Jang-Su. Chemosphere (2007), 68(7), 1204-1209.


14. Two functional domains of human heat shock factor 1 have different effects on its DNA-binding activity through redox changes. Lu, Ming; Kim, Hee-Eun; Li, Chun-Ri; Hwang, Yun-Jeong; Kim, Sol; Kwak, Im-Jung; Lee, Yun-Ju; Kim, So-Sun; Kang, Shin-Won; Park, Nam-Gyu; Kim, Dong-Kyoo; Kang, Ho Sung; Park, Jang-Su. Bulletin of the Korean Chemical Society (2007), 28(9), 1455-1456.


13. 3-chloro-2,5-dihydroxybenzyl alcohol activates human cervical carcinoma HeLa cell apoptosis by inducing DNA damage. Zhang, Yanjun; Ahn, Eun-Young; Jiang, Yahong; Kim, Dong-Kyoo; Kang, Sung-Goo; Wu, Chunfu; Kang, Shin-Won; Park, Jang-Su; Son, Byeng Wha; Jung, Jee H. International Journal of Oncology (2007), 31(6), 1317-1323.


12. An impedimetric immunosensor for the label-free detection of bisphenol A. Rahman, Md. Aminur; Shiddiky, Muhammad J. A.; Park, Jang-Su; Shim, Yoon-Bo. Biosensors & Bioelectronics (2007), 22(11), 2464-2470.


11. Development of a sandwich enzyme-linked immunosorbant assay for the quantification of vitellogenin in Bullfrog (Rana catesbeiana). Li, Chun-Ri; Jung, Kwun-Soon; Lee, Sang-Hoon; Kim, Andre; Park, Jang-Su. Chemosphere (2006), 63(9), 1485-1490.


10. Structure of tightly membrane-bound mastoparan-X, a G-protein-activating peptide, determined by solid-state NMR. Todokoro, Yasuto; Yumen, Ikuko; Fukushima, Kei; Kang, Shin-Won; Park, Jang-Su; Kohno, Toshiyuki; Wakamatsu, Kaori; Akutsu, Hideo; Fujiwara, Toshimichi. Biophysical Journal (2006), 91(4), 1368-1379.


9. Analysis of polymerase chain reaction amplifications through phosphate detection using an enzyme-based microbiosensor in a microfluidic device. Shiddiky, Muhammad J. A.; Rahman, Md. Aminur; Park, Jang-Su; Shim, Yoon-Bo. Electrophoresis (2006), 27(14), 2951-2959.


8. A novel enzyme-linked immunosorbent assay system for the quantitative analysis of Carassius auratus vitellogenin. Li, Chun-Ri; Kim, Kwang-Tae; Kang, Yun-Ju; Kim, Andre; Kang, Shin-Won; Park, Jang-Su. Chemosphere (2005), 59(7), 997-1003.


7. Identification of the structural change of human replication protein A (hRPA) in the ssDNA binding and redox potential. Kim, Suhkmann; Kim, Andre; Li, Chun-Ri; Kang, Shin-Won; Park, Jang-Su. Bulletin of the Korean Chemical Society (2005), 26(8), 1168-1169.


6. Modulation of the specific interaction of cardiolipin with cytochrome c by Zwitterionic Phospholipids in Binary Mixed Bilayers: A 2H- and 31P-NMR study. Kim, Andre; Jeong, In-Chul; Shim, Yoon-Bo; Kang, Shin-Won; Park, Jang-Su. Journal of Biochemistry and Molecular Biology (2005), 38(6), 766.


5. Mechanism of cell cycle arrest by (8E, 13Z, 20Z)-strobilinin/(7E,13Z,20Z)-felixinin from a marine sponge Psammocinia sp. Jiang, Yahong; Ahn, Eun-Young; Ryu, Seung-Hee; Kim, Dong-Kyoo; Park, Jang-Su; Kang, Shin Won; You, Song; Lee, Burm-Jong; Jung, Jee H. Oncology Reports (2005), 14(4), 957-962.


4. Involvement of Subcomplexes of 32 - and 14 - kDa Subunits in RPA ` s DNA Binding Activity through Redox Change. Jang - Su Park , and Andre Kim . Mol . Cells 2002 , 13 ( 3 ) , 493 - 497 .


3. Species specificity of human RPA in simian virus 40 DNA replication lies in T - antigen - dependent RNA primer synthesis. Jang - Su Park , Mu Wang , Masamichi Ishiai , Jerard Hurwitz , Suk - Hee Lee. Nucleic Acid Research . 2000 , 28 ( 23 ) , 4742 - 4749 .


2. Involvement of DNA - dependent Protein Kinase in UV - induced Replication Arrest. Jang - Su Park , Mu Wang , Suk - Hee Lee , J . Biol . Chem . 1999 , 274 ( 45 ) , 32520 - 32527 .


1. Zinc Finger of Replication Rrotein A , a Non - DNA Binding Element , Regulates Its DNA Binding Activity through Redox. Jang - Su Park , Mu Wang , Su - Jung Park , Suk - Hee Lee , J . Biol . Chem . 1999 , 274 ( 41 ) , 29075 - 29080 .