정재훈  사진
정재훈
영문이름
직위(직급)
교수
전화번호
051-510-2277
팩스번호
이메일
molecule85@pusan.ac.kr
홈페이지
http://lmg.pusan.ac.kr
연구실
교수연구실(C501-509), 분자유전학실(C501-501)

 




























?주요 이력
?

1985.03. - 1989.02. 부산대학교
(이학사-분자생물학)




1989.03. - 1991.02. 부산대학교
(이학석사-미생물학)




1991.03. - 1995.02. 일본 카나자와대학교
(이학박사-분자생물학)




1995.08. - 1998.12. 미국 NIH post-doc.
연구원




1999.02. - 2002.02. 전남대학교
조교수




2002.03. - 2004.08. 부산대학교
조교수




2004.08. - 2010. 부산대학교 부교수




2010. - 현 재 부산대학교
교수




2014. - 현 재 BK21 플러스 사업단장
(장수해양바이오사업단)


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?주요 연구분야

?


1. 간염바이러스에 의한 대사증후군 조절기전



2. 간염바이러스의 복제조절 기작



3. 대사중간물질에 의한 미토콘드리아
기능 조절


?주요 연구업적
?

1. Curcumin inhibits hepatitis C virus replication via suppressing
the Akt-SREBP-1 pathway.
Kim K, Kim KH,
Kim HY, Cho HK, Sakamoto N, Cheong J. FEBS Lett. 2009 Dec 17.




2. Anti-invasive activity of histone deacetylase inhibitors via the
induction of Egr-1 and the modulation of tight junction-related proteins in
human hepatocarcinoma cells.
Kim SO, Choi BT,
Choi IW, Cheong J, Kim GY, Kwon TK, Kim ND, Choi YH. BMB Rep. 2009
10:655-660.




3. Activating transcription factor 2 increases transactivation and
protein stability of hypoxia-inducible factor 1alpha in hepatocytes.
Choi
JH, Cho HK, Choi YH, Cheong J. Biochem J. 2009 424:285-296.




4. Hepatitis C virus NS5A protein increases hepatic lipid
accumulation via induction of activation and expression of PPARgamma.
Kim
K, Kim KH, Ha E, Park JY, Sakamoto N, Cheong J. FEBS Lett. 2009
583:2720-2726.




5. An immune responsive complement factor D/adipsin and
kallikrein-like serine protease (PoDAK) from the olive flounder Paralichthys
olivaceus.
Kong HJ, Hong GE, Nam BH, Kim YO, Kim WJ, Lee SJ, Lee NS, Do JW, Cho
HK, Cheong J, Lee CH, Kim KK. Fish Shellfish Immunol. 2009
27:486-492.




6. Molecular cloning and characterization of olive flounder
(Paralichthys olivaceus) peroxisome proliferator-activated receptor gamma.
Cho
HK, Kong HJ, Nam BH, Kim WJ, Noh JK, Lee JH, Kim YO, Cheong J. Gen Comp
Endocrinol. 2009 163:251-258.




7. Oleic acid inhibits hepatic insulin signaling through deregulation
of STAT3 activation and C/EBPalpha expression.
Kim K, Kim HY,
Son EJ, Heo J, Cheong J. Cell Signal. 2009 21:1269-1276.




8. The orphan nuclear receptor SHP inhibits apoptosis during the
monocytic differentiation by inducing p21WAF1.
Kim K, Choi YH,
Kim HH, Cheong J. Exp Mol Med. 2009 41:429-439.




9. Homeodomain transcription factor CDX1 is required for the
transcriptional induction of PPARgamma in intestinal cell differentiation.
Park
MJ, Kim HY, Kim K, Cheong J. FEBS Lett. 2009 583:29-35.




10. Streptochlorin isolated from Streptomyces sp. Induces apoptosis
in human hepatocarcinoma cells through a reactive oxygen species-mediated
mitochondrial pathway.
Shin DY, Shin HJ,
Kim GY, Cheong J, Choi IW, Kim SK, Moon SK, Kang HS, Choi YH. J Microbiol
Biotechnol. 2008 18:1862-1868.




11. Molecular cloning of Kazal-type proteinase inhibitor of the
shrimp Fenneropenaeus chinensis.
Kong HJ, Cho HK,
Park EM, Hong GE, Kim YO, Nam BH, Kim WJ, Lee SJ, Han HS, Jang IK, Lee CH,
Cheong J, Choi TJ. Fish Shellfish Immunol. 2009 26:109-114.




12. Generation of expressed sequence tags for immune gene discovery
and marker development in the sea squirt, Halocynthia roretzi.
Kim YO, Cho HK,
Park EM, Nam BH, Hur YB, Lee SJ, Cheong J. J Microbiol Biotechnol. 2008
18:1510-1517.




13. Hepatitis B virus X protein induces lipogenic transcription
factor SREBP1 and fatty acid synthase through the activation of nuclear receptor
LXRalpha.
Kim K, Kim KH, Kim HH, Cheong J. Biochem J. 2008 416:219-230.




14. Bile acid induces expression of COX-2 through the homeodomain
transcription factor CDX1 and orphan nuclear receptor SHP in human gastric
cancer cells.
Park MJ, Kim KH, Kim HY, Kim K, Cheong J. Carcinogenesis. 2008
29:2385-2393.




15. Induction of apoptosis by streptochlorin isolated from
Streptomyces sp. in human leukemic U937 cells.
Park C, Shin HJ,
Kim GY, Kwon TK, Nam TJ, Kim SK, Cheong J, Choi IW, Choi YH. Toxicol In Vitro.
2008 22:1573-1581.




16. Identification of softness syndrome-associated candidate genes
and DNA sequence variation in the sea squirt, Halocynthia roretzi.
Cho HK, Nam BH,
Kong HJ, Han HS, Hur YB, Choi TJ, Choi YH, Kim WJ, Cheong J. Mar Biotechnol
(NY). 2008 10:447-456.




17. Bile acid regulates c-Jun expression through the orphan nuclear
receptor SHP induction in gastric cells.
Park WI, Park MJ,
An JK, Choi YH, Kim HY, Cheong J, Yang US. Biochem Biophys Res Commun. 2008
369437-369443.




18. Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma
AGS cells through activation of caspase-3.
Jin CY, Park C,
Cheong J, Choi BT, Lee TH, Lee JD, Lee WH, Kim GY, Ryu CH, Choi YH. Cancer Lett.
2007 257:56-64.




19. Cutting edge: autoantigen Ro52 is an interferon inducible E3
ligase that ubiquitinates IRF-8 and enhances cytokine expression in
macrophages.
Kong HJ, Anderson DE, Lee CH, Jang MK, Tamura T, Tailor P, Cho HK,
Cheong J, Xiong H, Morse HC 3rd, Ozato K. J Immunol. 2007 179:26-30.




20. Hepatitis B virus X protein induces hepatic steatosis via
transcriptional activation of SREBP1 and PPARgamma.
Kim KH, Shin HJ,
Kim K, Choi HM, Rhee SH, Moon HB, Kim HH, Yang US, Yu DY, Cheong J.
Gastroenterology. 2007 132:1955-1967.




21. HIF-1alpha expression in response to lipopolysaccaride mediates
induction of hepatic inflammatory cytokine TNFalpha.
Kim HY, Kim YH,
Nam BH, Kong HJ, Kim HH, Kim YJ, An WG, Cheong J. Exp Cell Res. 2007
313:1866-1876.




22. HCV core protein induces hepatic lipid accumulation by activating
SREBP1 and PPARgamma.
Kim KH, Hong SP,
Kim K, Park MJ, Kim KJ, Cheong J. Biochem Biophys Res Commun. 2007 355:883-888.




23. Phosphorylation of the large subunit of replication factor C is
associated with adipocyte differentiation.
Park MJ, Lee MY,
Choi JH, Cho HK, Choi YH, Yang US, Cheong J. FEBS J. 2007 274:1235-1245.




24. Cloning and characterisation of the flounder (Paralichthys
olivaceus) interleukin-6 gene.
Nam BH, Byon JY,
Kim YO, Park EM, Cho YC, Cheong J. Fish Shellfish Immunol. 2007 :231-236.




25. Molecular mechanism of hypoxia-mediated hepatic gluconeogenesis
by transcriptional regulation. Ch
oi JH, Park MJ,
Kim KW, Choi YH, Park SH, An WG, Yang US, Cheong J. FEBS Lett. 2005
579:2795-2801.


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?협동연구희망분야
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