주요 이력

1999.03. - 2005.02. 성균관대학교 (이학사-생명과학)

2005.03. - 2012.02. 포항공과대학교 (이학박사-생명과학/분자세포생물학)

2012.03. - 2014.08. 포항공과대학교 박사후연구원, 연구교수

2014.09. - 2016.02. St. Jude Children’s Research Hospital, USA 박사후연구원

2016.03. - 2022.02  대구한의대학교 조교수

2022.03. - present   부산대학교 자연과학대학 분자생물학과 조교수

 주요 연구분야

- RNA binding protein
- Post-transcriptional regulation
- Circadian rhythm
- Amyotrophic Lateral Sclerosis

 주요 연구업적

1.     Lee, K.H., Do H.K., Kim, D.Y., Kim W. (2021). Impact of chlorogenic acid on modulation of significant genes in dermal fibroblasts and epidermal keratinocytes. Biochem Biophys Res Commun 583, 22-28.

2.     Kim, H.J., Kim, T.J., Kim, Y.G., Seong, C., Cho, J.H., Kim, W.^#, Lee, K.H.^#, Kim, D.Y.^# (2021). Antioxidant and antiproliferative activity of Finasteride against glioblastoma cells. Pharmaceutics 13, 1410. (^#co-corresponding author)

3.     Ryu, H.G., Jung, Y., Lee, N., Seo, J.Y., Kim, S.W., Lee, K.H., Kim, D.Y., and Kim, K.T. (2021). HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation. Int J Mol Sci 22.

4.     Kim, W., Jeong H.S., Kim, S.C., Choi, C.H., and Lee, K.H. (2021). Chronic alcohol exposure of cells using controlled alcohol-releasing capillaries. Cells 10, 1120

5.     Lee, K.H., Kim, D.Y., and Kim, W. (2021). Cultivation of human skin cells under physiological oxygen concentration modulates expression of skin significant genes and response to hydroxy acids. Biochem Biophys Res Commun 551, 161-167.

6.     Kim, W., Kim, D.Y., and Lee, K.H. (2021). RNA-Binding Proteins and the Complex Pathophysiology of ALS. Int J Mol Sci 22, 2598.

7.     Lee, K.H., and Kim, W. (2020). Roles of Fisetin on Skin Barrier Function and Anti-aging in Epidermal Keratinocyte. Journal of the society of cosmetic scientists of korea 46, 391-401.

8.     Lee, K.H., Lee, J.P., and Kim, W. (2020). Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells. Sci Rep 10, 22132.

9.     Jung, Y., Seo, J.Y., Ryu, H.G., Kim, D.Y., Lee, K.H., and Kim, K.T. (2020). BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1. Sci Adv 6.

10.  Kim, W., Shin, J.C., Lee, K.H.^#, and Kim, K.T.^# (2020b). PTBP1 Positively Regulates the Translation of Circadian Clock Gene, Period1. Int J Mol Sci 21. 6921. (^#co-corresponding author)

11.  Kim, W., Lee, E.J., Bae, I.H., Myoung, K., Kim, S.T., Park, P.J., Lee, K.H., Pham, A.V.Q., Ko, J., Oh, S.H., et al. (2020a). Lactobacillus plantarum-derived extracellular vesicles induce anti-inflammatory M2 macrophage polarization in vitro. J Extracell Vesicles 9, 1793514.

12.  Kwon, P.K., Lee, K.H., Kim, J.H., Tae, S., Ham, S., Jeong, Y.H., Kim, S.W., Kang, B., Kim, H.M., Choi, J.H., et al. (2020). hnRNP K Supports High-Amplitude D Site-Binding Protein mRNA (Dbp mRNA) Oscillation To Sustain Circadian Rhythms. Molecular and cellular biology 40.

13.  Jung, Y., Ryu, H.G., Kim, S.W., Lee, K.H., Gu, S., Yi, H., Ku, H.-O., Jang, S.K., and Kim, K.-T. (2019). The RNA-binding protein hnRNP Q represses translation of the clock gene Bmal1 in murine cells. J. Biol. Chem. jbc.RA118.006947.

14.  Kim, W., Kim, D.-Y., and Lee, K.H. (2019). Ultraviolet-C (UVC) ray acts as a synchronizing cue for circadian rhythm control in murine fibroblast. Biochemical and Biophysical Research Communications. 512, 344-351

15.  Kang, M., Lee, S.M., Kim, W., Lee, K.H., and Kim, D.-Y. (2019). Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2. Biochemical and Biophysical Research Communications 512, 93?99.

16.  Kim, T.-J., Kwon, H.-S., Kang, M., Leem, H.H., Lee, K.H.^#, and Kim, D.-Y^#. (2018). The Antitumor Natural Compound Falcarindiol Disrupts Neural Stem Cell Homeostasis by Suppressing Notch Pathway. Int J Mol Sci 19, 3432. (^#co-corresponding author)

17.  Kim, W., Na, K.Y., Lee, K.H., Lee, H.W., Lee, J.K., and Kim, K.T. (2017). Selective uptake of epidermal growth factor-conjugated gold nanoparticle (EGF-GNP) facilitates non-thermal plasma (NTP)-mediated cell death. Sci Rep 7, 10971.

18.  Seo, J.Y., Kim, D.Y., Kim, S.H., Kim, H.J., Ryu, H.G., Lee, J., Lee, K.H., and Kim, K.T. (2017). Heterogeneous nuclear ribonucleoprotein (hnRNP) L promotes DNA damage-induced cell apoptosis by enhancing the translation of p53. Oncotarget 8, 51108-51122.

19.  Kim, H.J., Lee, H.R., Seo, J.Y., Ryu, H.G., Lee, K.H., Kim, D.Y., and Kim, K.T. (2017). Heterogeneous nuclear ribonucleoprotein A1 regulates rhythmic synthesis of mouse Nfil3 protein via IRES-mediated translation. Sci Rep 7, 42882.

20.  Lee, K.H.^*, Zhang, P.^*, Kim, H.J.^*, Mitrea, D.M., Sarkar, M., Freibaum, B.D., Cika, J., Coughlin, M., Messing, J., Molliex, A., et al. (2016). C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell 167, 774-788 e717. (^*co-first author)

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