장세복  사진
장세복
영문이름
직위(직급)
교수 / 생명시스템연구소 소장
전화번호
051-510-2523
팩스번호
이메일
sbjang@pusan.ac.kr
홈페이지
http://sbjang.pusan.ac.kr
연구실
교수연구실(C501-409), 구조생물학실(C501-401)
 주요 이력

1992. - 1995. 부산대학교 (X-선 구조결정학) 이학박사


1996. - 1998. 미국 Lawrence Berkeley National Lab., UC. Berkeley 박사후 연구원


1998. - 2000. 미국 Utah State University 박사후 연구원


2000. - 2002. 포항공과대학교 연구 조교수


2002. - 2006. 부산대학교 한국나노바이오테크놀러지 조교수


2005. - 2007. 부산대학교 생물정보학 협동과정 전공 주임


2006. - 2010 부산대학교 자연과학대학 분자생물학과 부교수


2008. - 2009. 미국 Weill Medical college of Cornell University 방문교수


2011. - 현 재 부산대학교 자연과학대학 분자생물학과 교수


2013.02 - 2015.02 부산대학교 자연과학대학 분자생물학과 학과장

 

 주요 연구분야

 

1. Study on the biochemical functions and three dimensional structures of proteins and nucleotides by using X-ray diffraction method

2. Study on the target to promote and activate transcription regulation through the identification of the mechanism of the molecular level

3. Development the new medicine by the design of molecule to regulate cell proliferation and promote of tumor-suppressor

 

 주요 연구업적

1. J. S. Park, K. M. Lee, M. S. Jeong, G. Jin, and S. B. Jang (2007) The Binding of Human CLIC1 with SEDL and Its Characterization in vitro, Bull. Korean Chem. Soc., 28(4), 574-580.


2. M. S. Jeong, J. S. Park, and S. B. Jang (2007) Cloning, Overexpression, Purification, and Characterization of RIP3 Truncation in Escherichia coli. Applied Biochemistry and Biotechnology, 141(2-3), 175-186.


3. M. S. Jeong, J. S. Park, S. H. Song, and S. B. Jang (2007) Characterization of Antibacterial Nano-particles from the Scallop, Ptinopecten yessoensis. Bioscience Biotechnology and Biochemistry, 71(9), 2242-2247.


4. S. B. Jang,* L. W. Hung, M. S. Jeong, E. L. Holbrook, X. Chen, D. H. Turner, and S. R. Holbrook* (2006) The Crystal Structure at 1.5 A Resolution of an RNA Octamer Duplex Containing Tendem G.U Base Pairs. Biophysical Journal, 90(12), 4530-4537. (*Co-corresponding authors).


5. H. S. Kim, J. M. Yi, H. Hirai, J. W. Huh, M. S. Jeong, S. B. Jang, C. G. Kim, N. Saitou, B. H. Hyun, W. H. Lee (2006) Human Endogenous Retrovirus (HERV)-R Family in Primates: Chromosomal Location, Gene Expression, and Evolution. Gene, 370, 34-42.


6. S. B. Jang,* M. S. Jeong, R. J. Carter, E. L. Holbrook, L. R. Comoli, and S. R. Holbrook* (2006) Novel Crystal Form of the Rom Protein. Acta Cryst., D62(6), 619-627. (*Co-corresponding authors)


7. M. S. Jeong, and S. B. Jang (2006) Purification and Characterization of Human FADD and c-FLIPs Expressed in Escherichia coli. Bull. Korean Chem. Soc., 27, 87-92.


8. M. S. Jeong, and S. B.Jang (2006) Electron Transfer and Nano-Scale Motions in Nitrogenase Fe-Protein, Current Nanoscience., 2(1), 33-41.


9. M. S. Jeong, K. M. Lee, and S. B. Jang (2005) Biological and Structural Charaterizations of Mutations in the X-linked Spondyloepiphyseal Dysplasia Tarda. EXCLI Journal, 4, 61-76.


10. M. S. Jeong, and S. B. Jang (2005) Crystallization and X-ray Crystallographic Studies of Wild-type and Mutant Tryptophan Synthase a-subunits from Escherichia coli. Molecules and Cells, 18(3), 374-382.


11. K. S. Park, M. S. Jeong, J. H. Kim, and S. B. Jang (2005) Overexpression and Purification of PDZ Domain-containing Proteins NHERF and E3KARP in Escherichia coli. Protein Expresssion and Purification, 40, 197-202.


12. A. J. Copik, B. Nocek, S. I. Swierczek, S. Ruebush, S. B. Jang, L. Meng, V. M. D'souza, J. W. Peters, B. Bennett, and R. C. Holz (2005) EPR and X-ray Crystallographic Characterization of the Product-Bound Form of the MnII-Loaded Methionyl Aminopeptidase from Pyrococcus furious. Biochemistry, 44(1), 121-129.


13. M. S. Jeong, and S. B. Jang (2004) Three Crystal Structures of Dehydrated Partially Co2+-Exchanged Zeolite A Treated with Potassium Vapor. Korea J. Crystallography, 15(2), 59-68.


14. M. S. Jeong, and S. B. Jang (2004) Structural Basis for the Changes in Redox Potential Observed in the Nitrogenase Fe Protein Phe135Trp with MgADP bound. Molecules and Cells, 18(3), 374-382.


15. M. S. Jeong, and S. B. Jang (2004) Structural and Functional Analysis of Nitrogenase Fe Protein with MgADP Bound and Amino Acid Substitutions. Journal of Life Science, 14(5), 752-760.


16. J. M. Yi, T. H. Kim, J. W. Huh, K. S. Park, S. B. Jang, H. M. Kim, and H. S. Kim (2004) Human Endogenous Retroviral Elements Belonging to the HERV-S f Family from Human Tissues, Cancer Cells, and Primates: Expression, Structure, Phylogeny and Evolution. Gene, 342(2), 283-92.


17. M. S. Jeong, J. K. Jeong, W. K. Lim, and S. B. Jang (2004) Structures of Wild-type and P28L/Y173F Tryptophan Synthase a-subunits from Escherichia coli., Biochemical and Biophysical Research Communications, 323, 1257-1264.


18. S. B. Jang, M. S Jeong, L. Seefeldt, and J. W. Peters (2004) Structural and Biochemical Implications of Single Amino Acid Substitutions in the Nucleotide-dependent Switch Regions of the Nitrogenase Fe Protein from Azotobactor vinelandii. Journal of Biological Inorganic Chemistry, 9(8), 1028-1033.


19. S. B. Jang, K. Baeyens, M. S. Jeong, Jr. J. SantaLucia, D. Turner, and S. R. Holbrook (2004) Structures of Two RNA Octamers Containing Tandem G.A Base Pairs. Acta Cryst., D60, 829-835.


20. M. S. Jeong, J. K. Jeong, K. S. Park, H. T. Kim, K. M. Lee, W. K. Lim, and S. B. Jang (2004) Crystallization and Preliminary X-ray Analysis of Tryptophan Synthase a-subunits from Escherichia coli. Acta Cryst., D60, 132-134.

 

 협동연구희망분야



























?주요 이력
?

1992. - 1995. 부산대학교 (X-선 구조결정학) 이학박사




1996. - 1998. 미국 Lawrence Berkeley National Lab., UC. Berkeley
박사후 연구원




1998. - 2000. 미국 Utah State
University 박사후 연구원




2000. - 2002. 포항공과대학교 연구 조교수




2002. - 2006. 부산대학교 한국나노바이오테크놀러지 조교수




2005. - 2007. 부산대학교 생물정보학 협동과정 전공 주임




2006. - 2010 부산대학교 자연과학대학 분자생물학과 부교수




2008. - 2009. 미국 Weill Medical college of Cornell University
방문교수




2011. - 현 재 부산대학교 자연과학대학 분자생물학과 교수




2013.02 - 2015.02 부산대학교 자연과학대학 분자생물학과 학과장


?


?주요 연구분야

?


1. Study on the biochemical functions and three dimensional structures of
proteins and nucleotides by using X-ray diffraction method



2. Study on
the target to promote and activate transcription regulation through the
identification of the mechanism of the molecular level



3. Development the
new medicine by the design of molecule to regulate cell proliferation and
promote of tumor-suppressor


?


?주요 연구업적
?

1. J. S. Park, K. M. Lee, M. S. Jeong, G. Jin, and S. B.
Jang (2007) The Binding of Human CLIC1 with SEDL and Its Characterization
in vitro, Bull. Korean Chem. Soc., 28(4),
574-580.




2. M. S. Jeong, J. S. Park, and S. B. Jang (2007) Cloning,
Overexpression, Purification, and Characterization of RIP3 Truncation
in
Escherichia coli. Applied Biochemistry and
Biotechnology,
141(2-3), 175-186.




3. M. S. Jeong, J. S. Park, S. H. Song, and S. B. Jang (2007) Characterization
of Antibacterial Nano-particles from the Scallop,
Ptinopecten yessoensis. Bioscience Biotechnology and
Biochemistry,
71(9), 2242-2247.




4. S. B. Jang,* L. W. Hung, M. S. Jeong, E. L. Holbrook, X.
Chen, D. H. Turner, and S. R. Holbrook*
(2006) The Crystal
Structure at 1.5 A Resolution of an RNA Octamer Duplex Containing Tendem G.U
Base Pairs.
Biophysical Journal, 90(12), 4530-4537.
(*Co-corresponding authors).




5. H. S. Kim, J. M. Yi, H. Hirai, J. W. Huh, M. S. Jeong, S. B.
Jang, C. G. Kim, N. Saitou, B. H. Hyun, W. H. Lee
(2006) Human Endogenous
Retrovirus (HERV)-R Family in Primates: Chromosomal Location, Gene Expression,
and Evolution.
Gene, 370, 34-42.




6. S. B. Jang,* M. S. Jeong, R. J. Carter, E. L. Holbrook, L. R.
Comoli, and S. R. Holbrook*
(2006) Novel Crystal
Form of the Rom Protein.
Acta Cryst., D62(6), 619-627.
(*Co-corresponding authors)




7. M. S. Jeong, and S. B. Jang (2006) Purification and
Characterization of Human FADD and c-FLIPs Expressed in
Escherichia coli. Bull. Korean Chem. Soc., 27, 87-92.




8. M. S. Jeong, and S. B.Jang (2006) Electron
Transfer and Nano-Scale Motions in Nitrogenase Fe-Protein,
Current Nanoscience., 2(1), 33-41.




9. M. S. Jeong, K. M. Lee, and S. B. Jang
(2005)
Biological and Structural Charaterizations of Mutations in the
X-linked Spondyloepiphyseal Dysplasia Tarda.
EXCLI Journal, 4, 61-76.




10. M. S. Jeong, and S. B. Jang
(2005)
Crystallization and X-ray Crystallographic Studies of Wild-type and
Mutant Tryptophan Synthase a-subunits from
Escherichia coli. Molecules and Cells, 18(3), 374-382.




11. K. S. Park, M. S. Jeong, J. H. Kim, and S. B. Jang (2005) Overexpression
and Purification of PDZ Domain-containing Proteins NHERF and E3KARP in
Escherichia coli. Protein Expresssion and Purification, 40, 197-202.




12. A. J. Copik, B. Nocek, S. I. Swierczek, S. Ruebush, S. B.
Jang, L. Meng, V. M. D'souza, J. W. Peters, B. Bennett, and R. C.
Holz

(2005)
EPR and X-ray Crystallographic Characterization of the
Product-Bound Form of the MnII-Loaded Methionyl Aminopeptidase from
Pyrococcus furious. Biochemistry, 44(1), 121-129.




13. M. S. Jeong, and S. B. Jang (2004) Three Crystal Structures of
Dehydrated Partially Co2+-Exchanged Zeolite A Treated with Potassium Vapor.
Korea J. Crystallography, 15(2), 59-68.




14. M. S. Jeong, and S. B. Jang (2004) Structural Basis
for the Changes in Redox Potential Observed in the Nitrogenase Fe Protein
Phe135Trp with MgADP bound.
Molecules and Cells, 18(3), 374-382.




15. M. S. Jeong, and S. B. Jang (2004) Structural and
Functional Analysis of Nitrogenase Fe Protein with MgADP Bound and Amino Acid
Substitutions.
Journal of Life Science, 14(5), 752-760.




16. J. M. Yi, T. H. Kim, J. W. Huh, K. S. Park, S. B. Jang, H.
M. Kim, and H. S. Kim
(2004) Human Endogenous
Retroviral Elements Belonging to the HERV-S f Family from Human Tissues, Cancer
Cells, and Primates: Expression, Structure, Phylogeny and Evolution.
Gene, 342(2), 283-92.




17. M. S. Jeong, J. K. Jeong, W. K. Lim, and S. B.
Jang

(2004)
Structures of Wild-type and P28L/Y173F Tryptophan Synthase
a-subunits from
Escherichia coli., Biochemical and Biophysical Research
Communications
, 323, 1257-1264.




18. S. B. Jang, M. S Jeong, L. Seefeldt, and J. W. Peters (2004) Structural and
Biochemical Implications of Single Amino Acid Substitutions in the
Nucleotide-dependent Switch Regions of the Nitrogenase Fe Protein from
Azotobactor vinelandii. Journal of Biological Inorganic
Chemistry
, 9(8), 1028-1033.




19. S. B. Jang, K. Baeyens, M. S. Jeong, Jr. J. SantaLucia, D.
Turner, and S. R. Holbrook
(2004) Structures of
Two RNA Octamers Containing Tandem G.A Base Pairs.
Acta Cryst., D60, 829-835.




20. M. S. Jeong, J. K. Jeong, K. S. Park, H. T. Kim, K. M. Lee,
W. K. Lim, and S. B. Jang (2004) Crystallization and Preliminary X-ray Analysis
of Tryptophan Synthase a-subunits from
Escherichia coli. Acta Cryst., D60, 132-134.


?


?협동연구희망분야
?