미생물학과

숙주에 질병을 유발하고 있는 병원성 미생물 (bacterial pathogen) 중에서도 특히 식중독, 설사 및 장티푸스의 원인균인 Salmonella 균 및 어류질병균인 Edwardsiella tarda 균을 대상으로 하며, 병원균이 숙주에 감염하여 질병을 유발하게 되는 기작 (mechanism) 과 더불어 병원균과 숙주와의 상호관계를 이해함으로써 여러 면역반응을 포함한 방어기전을 세포생물학적, 분자생물학적, 면역학적 방법을 통해 밝히는 연구를 수행.

• Bacterial pathogen 의 병원성 관련 생리학적ㆍ생화학적 특성 연구.
• Bacterial pathogen 의 유전체ㆍ단백체로부터 유용인자 탐색 및 기능 연구.
• Bacterial pathogen 의 병원성 유발 기작 (mechanism) 에 대한 연구.
• Bacterial pathogen 에 대한 숙주의 방어기전에 대한 연구.

1. Ah Young Yoo, Jong Earn Yu, Hyejin Yoo, Tae Ho Lee, Woon Ho Lee, Jeong-Il Oh, Ho Young Kang (2013) Role of sigma factor E in regulation of Salmonella Agf expression
   Biochemical and Biophysical Research Communications 430, 131-136
2. Chang-Ho Baek, Ho-Young Kang, Kenneth L. Roland, Roy Curtiss, III
   (2011) Lrp acts as both a positive and negative regulator for type 1 fimbriae production in Salmonella enterica serovar Typhimurium PLoS ONE 6, e516
3. Kang, Ho Young; Moon, Ki Hwan; Kim, Se Won; Bahk, Jeong Dong; Gal, Sang Wan; Cho, Kwang-Keun; Kim, Chul-Wook; Lee, John Hwa; Kim, Sam Woong
   (2011) An Efficient secretion of the protein fused to the AgfA signal sequence in Salmonella African Journal of Biotechnology 1684-5315

1. Jong Earn Yu , Ah Young Yoo , Kyoung-Hwa Choi , Jaeho Cha , Inseok Kwak , Ho Young Kang (2013) Identification of antigenic Edwardsiella tarda surface proteins and their role in pathogenesis
   Fish Shellfish Immunology 34, 673-682
2. Jong Earn Yu , Mi Young Cho , Jin-woo Kim , Ho Young Kang
   (2012) Large antibiotic-resistance plasmid of Edwardsiella tarda contributes to virulence in fish
   Microbial Pathogenesis 52, 259-266

1. Cho IR, Kaowinn S, Moon J, Soh J, Kang HY, Jung CR, Oh S, Song H, Koh SS, Chung YH
   (2015) Oncotropic H-1 parvovirus infection degrades HIF-1α protein in human pancreatic cancer cells independently of VHL and RACK1
   International journal of oncology
2. Cho IR, Kaowinn S, Song J, Kim S, Koh SS, Kang HY, Ha NC, Lee KH, Jun HS, Chung YH
   (2015)VP2 capsid domain of the H-1 parvovirus determines susceptibility of human cancer cells to H-1 viral infection
   Cancer gene therapy
3. Soodong Noh, Yunjeong Choe, Vellaiappillai Tamilavan, Myung Ho Hyun, Ho Young Kang, Haesik Yang (2015) Facile electrochemical detection of Escherichia coli using redox cycling of the product generated by the intracellular beta-D-galactosidase
   Sensors and Actuators B: Chemical

1. 2015. 8. 27, 2015년도 한국생명과학회 제56회 정기총회 및 국제학술대회, 대한민국
   ① Studying the pathogenesis of Edwardsiella tarda with new infection model, Carassius auratus
2. 2015. 5. 30, American Society for Microbiology 2015, 미국
   ①Zebrafish (Danio Rerio) Behavior after Infection with Edwardsiella tarda
3. 2014. 7. 6, Australian Society for Microbiology Annual Scientific Meeting, 호주
   ① Necrosis Activity of Extracellular Proteins secreted in Aeromonas hydrophila
   ② Host Behavior after Infection with Edwardsiella tarda on Zebrafish(Danio Rerio) Model
4. 2012. 6. 16, American Society for Microbiology 2012, 미국
   ① Duplicate flagelline Genes in Edwardsiella tarda
   ② Involvement of TolC in the Expression of sitA in Salmonella
5. 2011. 5. 21, American Society for Microbiology 2011, 미국
   ① Identification and Characterization of the Edwardsiella tarda Surface Antigen
   ② Contribution of Crp in the Edwardsiella tarda Pathogenesis